Agreed - drain block and manifolds before adding the AF.
You are correct that using this method always runs the risk of leaving the block dry if the tstat doesn't reopen.
Go online and look up the cooling system for your engine. Analyzing the flow paths will allow you to understand what will get filled, and how.
For instance, on a 350Mag the flow path is from the inlet on the lower unit to the raw water pump, to PS cooler then to cool fuel block, then to distribution block, sending it to manifolds and to water pump housing, then to tstat housing, to risers and IF tstat is open - to block.
So for me, running on muffs will get everything for certain, except maybe the block based on tstat position.
So my safest method if using the muffs - drain everything. Run on muffs with AF and fog (correct way based on fuel system). When finished, pull main hose off tstat housing and check for AF. Pour AF into hose until it comes out the tsat assembly as pure AF.
Many will suggest draining it all at the end - different discussion.
This year I invested $5 in a baby pool, and $29 in a submersible pump. I put 6 gallon AF in the pool and placed it under the lower unit, then put the muffs on the pump and put it in the pool. Plugged in and started (already drained everything first). Ran it until temp was reached (165). I pulled the main hose and everything including the block was pure AF. Better use of the $35 instead of the premade gravity system you buy online. No timing issues this way.