I am using the 4212's and they are hooked up to the N2K backbone. Right now they display fuel % for each tank while in the NAV screens. I also have an AIRMAR 800 N2K in the mix as well. The Raymarine autopilot also is hooked. Once any N2K device is attached to the backbone any N2K MFD can display it's information. But as you point out, the 4212's are already doing there job with nav and radar so why clutter up display even more with even more data. Can they display all that is being discussed, absolutely, but when do you say enough is enough? And who wants to constantly scroll through screens information to see what you want to or need to at any given moment.
I will be using the DSM150 to display many things, all of which are on separate pages that can be scrolled through when needed. It's primary use will be two fold, system monitor and fuel display. But I also configured a page to display water depth, temp and speed. That is wwhat makes N2K so versatile, display what you want where you want and in many places all at the same time if desired. You can also have N2K alarms set for them. i.e. low fuel or engine over temp etc. These alarms can be viewed and alarmed on all MFD's that support N2K alarms, some also support analog outputs for buzzers etc. So scrolling through a few different screens on the DSM150 is not an issue.
As to the engine data display, I currently have the quad gauges that I can glance at. So my thinking is to replace each quad gauge with an MFD like the GMI20 or i70. Those four MFD's would mostly stay on there designated purpose, RPM, Engine data etc. These displays can and will also display other N2K data on separate pages or screens as well. In my case, I have four 3.5" holes in my dash that would need to be replaced by something, so I am choosing to use MFD's when I go all digital. That doesn't mean I couldn't just use two displays and two block off plates either. But I want to have what I already have when I glance at the displays. RPM on one, Oil, Temp, and Voltage on the others. I might go in steps and only put one MFD for each engine at first and display RPM, oil and temp for each engine while still using the analog gauge for security until I trust the Abla-Combi for supplying data.
To give you a better idea, checkout the screen shots here:
http://www.maretron.com/products/dsm150.php
Keep in mind that most MFD's will display data this way and can be configured almost anyway you want.